Highmore was born on 14 February 1992 into a show business family. His mother, Sue Latimer, is a talent agent whose clients include actors Daniel Radcliffe and Imelda Staunton, and his father, Edward Highmore, is an actor. He has a younger brother named Albert ("Bertie"), born in 1995. Highmore's home is in Highgate, an area of North London.
Highmore was educated at a primary school in Hampstead Garden Suburb in Hampstead in North London, and at Highgate School, an independent school for boys in Highgate (also in North London), followed by Emmanuel College at the University of Cambridge, where he studied Spanish and Arabic.
- Vera Farmiga stated in an interview that she requested him for the role of Norman after seeing his movie 'The Art of Getting By' at the Sundance Film Festival and viewing his audition tape for the show. She told Carlton Cuse that if he cast Freddie in the role he would have his Norma. Source
- He was attracted to the role of Norman after getting bored with playing "the same character again and again." Source
- He had to take 6 months off filming in order to finish his university degree and filming had to work around it. Source
- Has stated that he rewatches "Psycho" before every new season of the show. Source